Lab Publications (2023-2017)


The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding.
Varin C, Cornil A, Houtteman D, Bonnavion P, de Kerchove d’Exaerde A. Nat Commun. 2023 Aug 17;14(1):4982. 
DOI: 10.1038/s41467-023-40677-0

Balance Between Projecting Neuronal Populations of the Nucleus Accumbens Controls Social Behavior in Mice.
Le Merrer J, Detraux B, Gandía J, De Groote A, Fonteneau M, de Kerchove d’Exaerde A, Becker JAJ. Biol Psychiatry. 2023 May 18:S0006-3223(23)01295-7. 
DOI: 10.1016/j.biopsych.2023.05.008


A lipid transfer protein ensures nematode cuticular impermeability. 
Njume, F. N., Razzauti, A., Soler, M., Perschin, V., Fazeli, G., Bourez, A., … & Laurent, P., iScience, 18 November 2022.
DOI: 10.1016/j.isci.2022.105357


Thalamo-Nucleus Accumbens Projections in Motivated Behaviors and Addiction.
De Groote A, de Kerchove d’Exaerde A. . Front Syst Neurosci. 2021 Jul 15;15:711350.

Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons.

Razzauti, A. & Laurent, P., eLife, 2021.
DOI: 10.7554/eLife.67670

The effect of the serotonin 5-HT1B receptor on lateral inhibition between spiny projection neurons in the mouse striatum
Pommer S., Akamine Y., Schiffmann S.N., de Kerchove d’Exaerde A., Wickens J.R.. Journal of Neuroscience, 41(37): 7831-7847, 2021
DOI 10.1523/JNEUROSCI.1037-20.2021

Drug addiction: From bench to bedside.
Cheron J. & de Kerchove d’Exaerde A. Translational Psychiatry, 11: 424, 2021.
DOI 10.1038/s41398-021-01542-0

Dorsal and ventral striatal neuronal subpopulations differentially disrupt male mouse copulatory behavior
Detraux B., Vilella A., De Groote A., Schiffmann S.N., Zoli M., de Kerchove d’Exaerde A., European Neuropsychopharmacology 49: 23–37, 2021.
DOI 10.1016/j.euroneuro.2021.03.007

Regulation of GluA1 phosphorylation by d-amphetamine and methylphenidate in the cerebellum. 
Cutando L., Puighermanal E., Castell L., Tarot P., Bertaso F., Bonnavion P., de Kerchove d’Exaerde A., Isingrini E., Galante M., Dallerac G., Pascoli V., Lüscher C., Giros B., Valjent E. Addiction Biology, 26: e12995, 2021.
DOI 10.1111/adb.12995


Primary proprioceptive neurons from human induced pluripotent stem cells: a cell model for afferent
Dionisi C., Raï M., Chazalon M., Schiffmann S.N., Pandolfo M., Scientific Reports, 10:7752, 2020.
DOI 10.1038/s41598-020-64831-6

mTOR-RhoA signalling impairments in direct striatal projection neurons induce altered behaviours and striatal physiology in mice
Rial D., Puighermanal E., Chazalon M., Valjent E., Schiffmann S.N., de Kerchove d´Exaerde A., Biological Psychiatry, 88:945-954, 2020
DOI 10.1016/j.biopsych.2020.05.029

Combining single-cell RNA-sequencing with a molecular atlas unveils new markers for Caenorhabditis elegans neuron classes 
Lorenzo, R., Onizuka, M., Defrance, M., Laurent, P., Nucleic Acids Research, 48(13):7119–7134, 2020.

Deep behavioural phenotyping reveals divergent trajectories of ageing and quantifies health state in C. elegans
Martineau, C.N., Baskaner, B., Seinstra, R.I., Schafer, W.R., Brown, A.E.D, Nollen, E.AA, Laurent, P. PLoS Computational Biology,  16(7):e1008002, 2020.
DOI: 10.1371/journal.pcbi.1008002 


GPR88 in D1R-Type and D2R-Type Medium Spiny Neurons Differentially Regulates Affective and Motor Behavior
Meirsman A. C., Ben Hamida S, Clarke E., de Kerchove d’Exaerde A., E. Darcq, B. L. Kieffer; 6(4) eNeuro, 0035-19, 2019.
DOI 10.1523/ENEURO.0035-19.2019

Route of Infection Strongly Impacts the Host-Pathogen Relationship
Demars A., Lison A., Machelart A., Van Vyve M., Potemberg G., Vanderwinden JM, De Bolle X., Letesson JJ, Muraille E., Frontiers in Immunology, 10: 1589, 2019.
DOI 10.3389/fimmu.2019.01589

Potentiation of imatinib by cilostazol in sensitive and resistant gastrointestinal stromal tumor cell lines involves YAP inhibition
Vandenberghe P., Delvaux M., Hagué P., Erneux C., Vanderwinden JM, Oncotarget, 10(19): 1798-1811, 2019.
DOI 10.18632/oncotarget.26734

Ablation of striatal somatostatin interneurons affects MSN morphology and electrophysiological properties and increases cocaine-induced hyperlocomotion in mice
A. Gazan, D. Rial, SN. Schiffmann, Eur J Neurosci. 51(6): 1388–1402, 2020.
DOI 10.1111/ejn.14581

Activation of adenosine A2A receptors in the olfactory tubercle promotes sleep in rodents
Li R., Wang Y.Q., Liu W.Y., Zhang M.Q., Li L., Cherasse Y., Schiffmann S.N., de Kerchove d’Exaerde A., Lazarus M., Qu W.M., Huang Z.L., Neuropharmacology. 168: 107923. 2020. 
DOI 10.1016/j.neuropharm.2019.107923

GPRIN3 controls neuronal excitability, morphology and striatal-dependent behaviors in the indirect pathway of the striatum
D. Karadurmus, D. Rial, J.-F. De Backer, D. Communi, A. de Kerchove d´Exaerde, S.N. Schiffmann. Journal of Neuroscience, 39(38): 7513-7528, 2019.
DOI 10.1523/JNEUROSCI.2454-18.2019

It takes two to tango: Dorsal direct and indirect pathways orchestration of motor learning and behavioral flexibility. 

Bonnavion P., Pozuelo Fernandez E., Varin C., de Kerchove d’Exaerde A., Neurochemistry international, 124, 200-214, 2019.
DOI 10.1016/j.neuint.2019.01.009

Pharmacosynthetic Deconstruction of Sleep-Wake Circuits in the Brain. 

Varin C. & Bonnavion P. Handbook of experimental pharmacology, 253, 153-206, 2019.
DOI 10.1007/164_2018_183


Alpha2-containing glycine receptors promote neonatal spontaneous activity of striatal medium spiny neurons and support maturation of glutamatergic inputs
Comhair J., J. Devoght, G. Morelli, R.J. Harvey, V. Briz, S.C. Borrie, C. Bagni, J.-M. Rigo, S.N. Schiffmann, D. Gall, B. Brone, S.M. Molchanova. Frontiers in Molecular Neuroscience, 11: 380. 2018.
DOI 10.3389/fnmol.2018.00380

Deletion of Maged1 in mice abolishes locomotor and reinforcing effets of cocaine
De Backer J.-F., S. Monlezun, B. Detraux, A. Gazan, L. Vandopdenbosch, J. Cheron, G. Cannazza, S. Valverde, L. Cantacorps, M. Nassar, L. Venance, O. Valverde, P. Faure, M. Zoli, O. De Backer, D. Gall, S.N. Schiffmann, A. de Kerchove d’Exaerde. EMBO reports, 19: e45089, 1-17, 2018.
DOI 10.15252/embr.201745089

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
Temido-Ferreira M., Ferreira D.G., Batalha V.L., Marques-Morgado I., Coelho J.E., Pereira P., Gomes R., Pinto A., Carvalho S., Canas P.M, Cuvelier L., Buee-Scherrer V., Faivre E., Baqi Y., Muller C.E., Pimentel J., Schiffmann S.N., Buee L., Bader M., Outeiro T.F., Blum D., Cunha R.A., Marie H., Pousinha P.A., Lopes L.V, Molecular Psychiatry, 2018.
DOI 10.1038/s41380-018-0110-9 

Dopamine-endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
Xu H., Perez S., Cornil A., Detraux B., Prokin I., Cui Y., Degos B., Berry H., de Kerchove d’Exaerde A., Venance L., Nature Communication, 9:4118, 2018.
DOI 10.1038/s41467-018-06409-5

Allergic Asthma Favors Brucella Growth in the Lungs of Infected Mice
Machelart A, Potemberg G.,Van Maele L., Demars A., Lagneaux M., De Trez C., Sabatel C., Bureau F., De Prins S., Percier P., Denis O., Jurion F., Romano M., Vanderwinden JM, Letesson J-J, Muraille E., Frontiers in Immunology 8 (1856), 2018.
DOI 10.3389/fimmu.2018.01856

Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons
Molchanova SM, Comhair J, Karadurmus D, Piccart E, Harvey RJ, Rigo JM, Schiffmann SN, Brone B, Gall D., Frontiers in Molecular Neuroscience, 10:442, 2018.
DOI 10.3389/fnmol.2017.00442

The GABAergic Gudden’s dorsal tegmental nucleus: a new relay for serotonergic regulation of sleep-wake behavior in the mouse.
Chazalon M., Dumas S., Bernard J.-F., Sahly I., Tronche F., de Kerchove d’Exaerde A., Hamon M., Adrien J., Fabre V.*, Bonnavion P.* Neuropharmarcology, 138:315-30, 2018. *co-last authors.
DOI 10.1016/j.neuropharm.2018.06.014

Genetic dissection of neuropeptide cell biology at high and low activity in a defined sensory neuron
Laurent, P., Ch’ng, Q., Jospin, M., Chen, CC., Lorenzo, R., de Bono, M., PNAS 115(29): E6890-E6899, 2018.
DOI 10.1073/pnas.1714610115


Bidirectional control of reversal in a dual action task by direct and indirect pathway activation in the dorsolateral striatum in mice
Laurent M., De Backer J.-F., Rial D., Schiffmann S.N., de Kerchove d’Exaerde A.,  Frontiers in Behavioral Neurosciences, 2017.
DOI 10.3389/fnbeh.2017.00256

Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice
Oishi O., Wang L., Zhang B-J., Takahashi K., Takata U., Luo Y-J., Cherasse Y., Schiffmann S.N., de Kerchove d’Exaerde A., Urade Y., Qu W-M., Huang Z-L., Lazarus M., Nature Communications, 2017. (12.124)
DOI 10.1038/s41467-017-00781-4

Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST).
Vandenberghe P., Hagué P., Hockman S.C.,  Manganiello V.C, Demetter P., Erneux C., Vanderwinden J.M., Oncotarget, 20;8: 41026-41043, 2017.
DOI 10.18632/oncotarget.17010

Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus
Xiang-Shan Y., Wang L., Dong H., Qu W.-M., Yang S-R., Cherasse Y., Lazarus M., Schiffmann S.N., de Kerchove d’Exaerde A., Li R-X, Huang Z-L, eLife, 1-24, 2017.
DOI 10.7554/eLife.29055

A framework for simulating gastric electrical propagation in confocal microscopy derived geometries
Krohn B, Sathar S, Rohrle O, Vanderwinden JM, O’Grady G, Cheng LK, Conf Proc IEEE Eng Med Biol Soc 2017: 4215-4218, 2017.
DOI 10.1109/EMBC.2017.8037786

Distinct Roles of Ventromedial versus Ventrolateral Striatal Medium Spiny Neurons in Reward-Oriented Behavior
Tsutsui-Kimura I., Natsubori A., Mori M., Kobayashi K., Drew M.R., De Kerchove D’exaerde A., Mimura M., Tanaka K.F., Current Biology 27:3042-3048, 2017.
DOI 10.1016/j.cub.2017.08.061

Ventrolateral Striatal Medium Spiny Neurons Positively Regulate Food-Incentive, Goal-Directed Behavior Independently of D1 and D2 Selectivity
Natsubori A., Tsutsui-Kimura I., Nishida H., Bouchekioua Y., Sekiya H., Uchigashima M., Watanabe M., de Kerchove d’Exaerde A., Mimura M., Takata N., Tanaka K.F. Journal of Neuroscience, 37(10): 2723-2733, 2017.
DOI 10.1523/JNEUROSCI.3377-16.2017

Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability.

Fujita A.*, Bonnavion P.*#, Wilson M.H., Mickelsen L.E., Bloit J., de Lecea L., Jackson A.C. Journal of Neuroscience, 37: 9574-92, 2017. *co-first, #co-corresponding authors.
DOI 10.1523/JNEUROSCI.0580-17.2017

IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses
Chen, C.C., Itakura, E., Nelson, G.M, Sheng, M., Laurent, P., Fenk A.L., Butcher, R.A., Hegde, R.S., De Bono, M., Nature 542, 43–48, 2017.
DOI 10.1038/nature20818