Maged1 and USP7 in a new unexpected mechanism involved in drug dependence

Published in Nature Communication, our study unveils a novel mechanism involving the gene Maged1, which surprisingly operates outside the anticipated reward circuit, within the paraventricular thalamus region of the brain. This unexpected finding sheds light on specific epigenetic modifications, altering DNA structure and influencing gene expression. We identified USP7 as a crucial partner in these […]

A lipid transfer protein ensures nematode cuticular impermeability

At the origin of many discoveries, the nematode C. elegans has forged a solid reputation as a genetic model organism. Its use as a pharmacological model is however limited: its cuticle is impermeable to chemicals, toxins and pathogens. Increased permeability is therefore a desirable phenotype as it would facilitate chemical absorption. We identified a mutant […]

Paper Release on mTOR signaling

Neurophy Lab - Paper Release on mTOR signalling

Mammalian Target of Rapamycin-RhoA Signaling Impairments in Direct Striatal Projection Neurons Induce Altered Behaviors and Striatal Physiology in Mice. DOI: 10.1016/j.biopsych.2020.05.029